Distribution of E-selectin gene polymorphism in the Zhuangs and Hans of Guangxi province in China
韦叶生 蓝艳 杜诗库
摘 要:目的研究E-选择素(E-selectin)基因第2外显子G98T和第4外显子S128R遗传多态性在广西壮、汉两民族中的分布.方法采用聚合酶链反应-限制性片段长度多态性和DNA序列测定法检测162名壮族人和170名汉族人E-选择素基因第2外显子G98T和第4外显子S128R遗传多态性,比较两组E-选择素基因型和等位基因的分布频率.结果 E-选择素基因第2外显子等位基因G、T频率在壮族与汉族正常人群中分别为94.8%、5.2%和95.3%、4.7%;第4外显子等位基因S、R频率分别为92.0%、8.0%和95.9%、4.1%(χ2=4.482,P=0.034).结论 E-选择素基因 S128R多态性在广西壮、汉两民族中差异有显著性;E-选择素基因G98T多态性在广西壮、汉两民族中差异无显著性.
关键词:E-选择素基因;遗传多态性;壮族;汉族
基金项目:广西省教育厅基金(200420)
作者单位:韦叶生(533000,百色,广西右江民族医学院附属医院检验科)
蓝艳(533000,百色,广西右江民族医学院附属医院皮肤科)
杜诗库(533000,百色,广西右江民族医学院附属医院检验科)
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中华医学遗传学杂志
CHINESE JOURNAL OF MEDICAL GENETICS
2004 Vol.21 No.6 P.643-645
收稿日期:2003年12月20日
出版日期:2004年12月10日
[此贴子已经被作者于2005-5-19 17:10:37编辑过]