请选择 进入手机版 | 继续访问电脑版
设为首页收藏本站

僚人家园

 找回密码
 注册

QQ登录

只需一步,快速开始

点击进入授权页面

只需一步,快速开始

扫一扫,访问微社区

搜索
查看: 2406|回复: 2

广西壮族与汉族人群E-选择素基因的遗传多态性(摘要)

[复制链接]

803

主题

1

听众

3万

积分

超级版主

Rank: 13Rank: 13Rank: 13Rank: 13Rank: 13Rank: 13Rank: 13Rank: 13Rank: 13Rank: 13Rank: 13Rank: 13Rank: 13

最后登录
2017-3-29
注册时间
2002-7-5
发表于 2005-5-19 17:07:00 |显示全部楼层


Distribution of E-selectin gene polymorphism in the Zhuangs and Hans of Guangxi province in China

韦叶生  蓝艳  杜诗库 

摘 要:目的研究E-选择素(E-selectin)基因第2外显子G98T和第4外显子S128R遗传多态性在广西壮、汉两民族中的分布.方法采用聚合酶链反应-限制性片段长度多态性和DNA序列测定法检测162名壮族人和170名汉族人E-选择素基因第2外显子G98T和第4外显子S128R遗传多态性,比较两组E-选择素基因型和等位基因的分布频率.结果 E-选择素基因第2外显子等位基因G、T频率在壮族与汉族正常人群中分别为94.8%、5.2%和95.3%、4.7%;第4外显子等位基因S、R频率分别为92.0%、8.0%和95.9%、4.1%(χ2=4.482,P=0.034).结论 E-选择素基因 S128R多态性在广西壮、汉两民族中差异有显著性;E-选择素基因G98T多态性在广西壮、汉两民族中差异无显著性.
关键词:E-选择素基因;遗传多态性;壮族;汉族


基金项目:广西省教育厅基金(200420)
作者单位:韦叶生(533000,百色,广西右江民族医学院附属医院检验科) 
     蓝艳(533000,百色,广西右江民族医学院附属医院皮肤科) 
     杜诗库(533000,百色,广西右江民族医学院附属医院检验科) 

参考文献:

Shyu KG, Chang H, Lin CC, et al. Circulating intercellular adhesion molecule-1 and E-selectin in patients with acute coronary syndrome. Chest, 1996, 109:1627-1630.
Blann AD, McCollum CN, Lip GY. Relationship between plasma markers of endothelial cell integrity and the Framingham cardiovascular disease risk-factor scores in apparently healthy individuals. Blood Coagul Fibrinolysis, 2002,13:513-518.
Ellsworth DL, Bielak LF, Turner ST, et al. Gender- and age-dependent relationships between the E-selectin S128R polymorphism and coronary artery calcification. J Mol Med,2001,79:390-398.
Wenzel K,Blackburn A,Ernst M,et al. Relationship of polymorphisms in the renin-angiotensin system and in E-selectin of patients with early severe coronary heart disease. J Mol Med, 1997, 75:57-61.
Ye SQ, Usher D, Virgil D, et al. A PstⅠ polymorphism detects the mutation of serine128 to arginine in CD 62E gene-a risk factor for coronary artery disease. J Biomed Sci,1999,6:18-21.
Bannan S,Mansfield MW,Grant PJ. Soluble vascular cell adhesion molecule-1 and E-selectin levels in relation to vascular risk factors and to E-selectin genotype in the first degree relatives of NIDDM patients and in NIDDM patients. Diabetologia, 1998,41:460-466.
El-Magadmi M, Alansari A, Teh LS, et al. Association of the A561C E-selectin polymorphism with systemic lupus erythematosus in 2 independent populations. J Rheumatol, 2001, 28:2650-2652.
Zheng F, Chevalier JA, Zhang LQ, et al. An HphⅠ polymorphism in the E-selectin gene is associated with premature coronary artery disease.Clin Genet, 2001, 59:58-64.
Rauchhaus M, Gross M, Schulz S, et al. The E-selectin SER128ARG gene polymorphism and restenosis after successful coronary angioplasty. Int J Cardiol, 2002,83:249-257.
Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acid Res, 1998, 16:1215.
Vogel M. Human Genetics. In: Translation by Luo HY. Human Genetics Problems and Approaches. 3rd ed. Beijing: People Health Publication, 1999. 749-750. [Vogel M. 人类遗传学. 见罗会元译. 人类遗传学问题与方法. 第3版. 北京: 人民卫生出版社, 1999. 749-750.]
Wenzel K, Felix S, Kleber FX, et al. E-selectin polymorphism and atherosclerosis: an association study. Hum Mol Genet, 1994, 3:1935-1937.
Wenzel K, Ernst M, Rohde K, et al. DNA polymorphisms in adhesion molecule genes: a new risk factor for early atherosclerosis. Hum Genet,1996, 97:15-20.


中华医学遗传学杂志
CHINESE JOURNAL OF MEDICAL GENETICS
2004 Vol.21 No.6 P.643-645
收稿日期:2003年12月20日
出版日期:2004年12月10日

[此贴子已经被作者于2005-5-19 17:10:37编辑过]

回复

使用道具 举报

683

主题

1

听众

5万

积分

版主

Rank: 12Rank: 12Rank: 12Rank: 12Rank: 12Rank: 12Rank: 12Rank: 12Rank: 12Rank: 12Rank: 12Rank: 12

最后登录
2020-5-27
注册时间
2003-12-15
发表于 2005-5-22 14:57:00 |显示全部楼层
“摘要”看不出什么名堂

登上僚人网站,认识僚人历史, 弘扬僚人文化,增强民族意识, 推动对外开放,促进僚区发展!
回复

使用道具 举报

0

主题

1

听众

561

积分

山精灵

Rank: 6Rank: 6Rank: 6Rank: 6Rank: 6Rank: 6

最后登录
2005-6-25
注册时间
2005-6-16
发表于 2005-6-20 22:16:00 |显示全部楼层
你到底想要说的是什么?

回复

使用道具 举报

您需要登录后才可以回帖 登录 | 注册  

允许回帖同步到新浪微博  

Archiver|手机版|壮族在线    

GMT+8, 2020-10-30 10:05 , Processed in 0.138258 second(s), 45 queries .

Powered by Discuz! X2.5

© 2001-2012 Comsenz Inc.

回顶部