两篇极好的基因论文
<div><br/></div><div><br/></div><div><br/></div><div><br/></div><div><span class="Apple-style-span" style="font-family: Arial, Helvetica, sans-serif; border-collapse: collapse; color: rgb(83, 83, 83); line-height: 22px; "><div style="word-wrap: break-word; line-height: normal; "><br style="word-wrap: break-word; line-height: normal; "/></div><div style="word-wrap: break-word; line-height: normal; "><span class="Apple-style-span" style="word-wrap: break-word; line-height: 19px; color: rgb(68, 68, 68); font-family: Verdana, Helvetica, Arial, sans-serif; font-size: 12px; border-collapse: collapse; "><div id="threadtitle" style="word-wrap: break-word; line-height: normal; margin-bottom: 8px; border-bottom-width: 1px; border-bottom-style: dashed; border-bottom-color: rgb(230, 231, 225); "><h1 style="word-wrap: break-word; margin-top: 8px; margin-right: 0px; margin-bottom: 8px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; font-size: 1.17em; line-height: normal; background-image: url(http://bbs.cantonese.asia/images/Beijing2008/forumbox_head.gif); background-attachment: initial; background-origin: initial; background-clip: initial; background-color: rgb(255, 255, 255); color: rgb(221, 0, 0); border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(226, 226, 226); background-position: 0px 0px; background-repeat: repeat no-repeat; ">珠江三角洲汉族人群的亚群分析</h1></div><div class="t_msgfontfix" style="word-wrap: break-word; line-height: normal; min-height: 100px; "><table cellspacing="0" cellpadding="0" style="word-wrap: break-word; empty-cells: show; border-collapse: collapse; line-height: normal; width: 600px; table-layout: fixed; margin-left: 1px; "><tbody style="word-wrap: break-word; line-height: normal; "><tr style="word-wrap: break-word; line-height: normal; "><td class="t_msgfont" id="postmessage_188" style="word-wrap: break-word; color: rgb(68, 68, 68); font: normal normal normal 12px/1.6em Verdana, Helvetica, Arial, sans-serif; line-height: 1.6em; font-size: 14px; border-top-width: 1px; border-top-style: solid; border-top-color: rgb(193, 193, 193); padding-top: 5px; padding-right: 5px; padding-bottom: 5px; padding-left: 5px; "><font color="#000000" style="word-wrap: break-word; line-height: normal; "><font face="宋体 " style="word-wrap: break-word; line-height: normal; "><br style="word-wrap: break-word; line-height: normal; "/>遗传</font><font face="Times New Roman " style="word-wrap: break-word; line-height: normal; "> 2003 25 (6): 645-648 <br style="word-wrap: break-word; line-height: normal; "/></font></font><br style="word-wrap: break-word; line-height: normal; "/><strong style="word-wrap: break-word; font-style: normal; font-weight: bold; line-height: normal; text-align: left; "><font face="宋体 " style="word-wrap: break-word; line-height: normal; "><font style="word-wrap: break-word; line-height: normal; font-size: 13.5pt; "><span href="tag.php?name=%BA%BA%D7%E5" class="t_tag" style="word-wrap: break-word; line-height: normal; cursor: pointer; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(255, 0, 0); white-space: nowrap; ">珠江三角洲汉族</span>人群的亚群分析<br style="word-wrap: break-word; line-height: normal; "/></font></font></strong><br style="word-wrap: break-word; line-height: normal; "/><font color="#000000" style="word-wrap: break-word; line-height: normal; "><font face="宋体 " style="word-wrap: break-word; line-height: normal; ">吕德坚</font><font face="Times New Roman " style="word-wrap: break-word; line-height: normal; ">,</font><font face="宋体 " style="word-wrap: break-word; line-height: normal; ">刘秋玲</font><font face="Times New Roman " style="word-wrap: break-word; line-height: normal; ">,</font><font face="宋体 " style="word-wrap: break-word; line-height: normal; ">陆惠玲</font></font><br style="word-wrap: break-word; line-height: normal; "/><font color="black" style="word-wrap: break-word; line-height: normal; "><font face="宋体 " style="word-wrap: break-word; line-height: normal; "><br style="word-wrap: break-word; line-height: normal; "/>中山大学中山医学院法医物证教研室，广州</font></font><br style="word-wrap: break-word; line-height: normal; "/><font color="#000000" style="word-wrap: break-word; line-height: normal; "><font style="word-wrap: break-word; line-height: normal; font-size: 9pt; "><strong style="word-wrap: break-word; font-style: normal; font-weight: bold; line-height: normal; text-align: left; "><font face="宋体 " style="word-wrap: break-word; line-height: normal; "><br style="word-wrap: break-word; line-height: normal; "/>摘要</font></strong></font><font face="Times New Roman " style="word-wrap: break-word; line-height: normal; "> </font><font face="宋体 " style="word-wrap: break-word; line-height: normal; "><font style="word-wrap: break-word; line-height: normal; font-size: 9pt; ">为调查珠江三角洲地区汉族人群中是否存在着亚群结构，对来自广州、佛山、东莞、江门和中山</font></font><font style="word-wrap: break-word; line-height: normal; font-size: 9pt; "><font face="Times New Roman " style="word-wrap: break-word; line-height: normal; ">-</font></font><font face="宋体 " style="word-wrap: break-word; line-height: normal; "><font style="word-wrap: break-word; line-height: normal; font-size: 9pt; ">珠海</font></font><font style="word-wrap: break-word; line-height: normal; font-size: 9pt; "><font face="Times New Roman " style="word-wrap: break-word; line-height: normal; ">5</font></font><font face="宋体 " style="word-wrap: break-word; line-height: normal; "><font style="word-wrap: break-word; line-height: normal; font-size: 9pt; ">个不同地区的</font></font><font style="word-wrap: break-word; line-height: normal; font-size: 9pt; "><font face="Times New Roman " style="word-wrap: break-word; line-height: normal; ">471</font></font><font face="宋体 " style="word-wrap: break-word; line-height: normal; "><font style="word-wrap: break-word; line-height: normal; font-size: 9pt; ">随机个体血样本进行</font></font><font style="word-wrap: break-word; line-height: normal; font-size: 9pt; "><font face="Times New Roman " style="word-wrap: break-word; line-height: normal; ">15</font></font><font face="宋体 " style="word-wrap: break-word; line-height: normal; "><font style="word-wrap: break-word; line-height: normal; font-size: 9pt; ">个</font></font><font style="word-wrap: break-word; line-height: normal; font-size: 9pt; "><font face="Times New Roman " style="word-wrap: break-word; line-height: normal; "><span href="tag.php?name=STR" class="t_tag" style="word-wrap: break-word; line-height: normal; cursor: pointer; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(255, 0, 0); white-space: nowrap; ">STR</span></font></font><font face="宋体 " style="word-wrap: break-word; line-height: normal; "><font style="word-wrap: break-word; line-height: normal; font-size: 9pt; ">的基因分型，并作</font></font><font style="word-wrap: break-word; line-height: normal; font-size: 9pt; "><font face="Times New Roman " style="word-wrap: break-word; line-height: normal; ">Hardy-Weinberg</font></font><font face="宋体 " style="word-wrap: break-word; line-height: normal; "><font style="word-wrap: break-word; line-height: normal; font-size: 9pt; ">平衡检验，比较群体之间的等位基因频率，计算这个</font></font><font style="word-wrap: break-word; line-height: normal; font-size: 9pt; "><font face="Times New Roman " style="word-wrap: break-word; line-height: normal; ">5</font></font><font face="宋体 " style="word-wrap: break-word; line-height: normal; "><font style="word-wrap: break-word; line-height: normal; font-size: 9pt; ">个地区人群间的共祖系数。结果显示，<b style="word-wrap: break-word; line-height: normal; "><font class="Apple-style-span" color="#0000FF" style="word-wrap: break-word; line-height: normal; ">珠江三角洲汉族人群</font></b></font></font><font face="宋体 " style="word-wrap: break-word; line-height: normal; "><font style="word-wrap: break-word; line-height: normal; font-size: 9pt; "><b style="word-wrap: break-word; line-height: normal; "><font class="Apple-style-span" color="#0000FF" style="word-wrap: break-word; line-height: normal; ">之间的共祖系数小于</font></b></font></font><font style="word-wrap: break-word; line-height: normal; font-size: 9pt; "><font face="Times New Roman " style="word-wrap: break-word; line-height: normal; "><b style="word-wrap: break-word; line-height: normal; "><font class="Apple-style-span" color="#0000FF" style="word-wrap: break-word; line-height: normal; ">0.01</font></b></font></font><font face="宋体 " style="word-wrap: break-word; line-height: normal; "><font style="word-wrap: break-word; line-height: normal; font-size: 9pt; ">。因此，珠江三角洲地区汉族人群中没有明显的亚群结构。<br style="word-wrap: break-word; line-height: normal; "/></font></font></font><br style="word-wrap: break-word; line-height: normal; "/><div style="word-wrap: break-word; line-height: normal; text-align: left; "><font class="Apple-style-span" color="#000000" face="宋体" size="3" style="word-wrap: break-word; line-height: normal; "><span class="Apple-style-span" style="word-wrap: break-word; line-height: normal; font-size: 12px; "><b style="word-wrap: break-word; line-height: normal; "><br style="word-wrap: break-word; line-height: normal; "/></b></span></font></div><font class="Apple-style-span" color="#535353" face="Arial, Helvetica, sans-serif" style="word-wrap: break-word; line-height: normal; "><span class="Apple-style-span" style="word-wrap: break-word; line-height: normal; border-collapse: separate; "><font class="Apple-style-span" color="#800080" face="宋体" style="word-wrap: break-word; line-height: normal; "><span class="Apple-style-span" style="word-wrap: break-word; line-height: normal; border-collapse: collapse; "><br style="word-wrap: break-word; line-height: normal; "/></span></font></span></font></td></tr></tbody></table></div></span></div><div style="word-wrap: break-word; line-height: normal; "><br style="word-wrap: break-word; line-height: normal; "/></div><div style="word-wrap: break-word; line-height: normal; "><br style="word-wrap: break-word; line-height: normal; "/></div><div style="word-wrap: break-word; line-height: normal; "><br style="word-wrap: break-word; line-height: normal; "/></div><div style="word-wrap: break-word; line-height: normal; "><span class="Apple-style-span" style="word-wrap: break-word; line-height: 19px; color: rgb(68, 68, 68); font-family: Verdana, Helvetica, Arial, sans-serif; font-size: 12px; border-collapse: collapse; "><div id="threadtitle" style="word-wrap: break-word; line-height: normal; margin-bottom: 8px; border-bottom-width: 1px; border-bottom-style: dashed; border-bottom-color: rgb(230, 231, 225); "><h1 style="word-wrap: break-word; margin-top: 8px; margin-right: 0px; margin-bottom: 8px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; font-size: 1.17em; line-height: normal; background-image: url(http://bbs.cantonese.asia/images/Beijing2008/forumbox_head.gif); background-attachment: initial; background-origin: initial; background-clip: initial; background-color: rgb(255, 255, 255); color: rgb(221, 0, 0); border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(226, 226, 226); background-position: 0px 0px; background-repeat: repeat no-repeat; ">邕宁汉族与周边民族的群体差异分析</h1></div><div class="t_msgfontfix" style="word-wrap: break-word; line-height: normal; min-height: 100px; "><table cellspacing="0" cellpadding="0" style="word-wrap: break-word; empty-cells: show; border-collapse: collapse; line-height: normal; width: 600px; table-layout: fixed; margin-left: 1px; "><tbody style="word-wrap: break-word; line-height: normal; "><tr style="word-wrap: break-word; line-height: normal; "><td class="t_msgfont" id="postmessage_2019" style="word-wrap: break-word; color: rgb(68, 68, 68); font: normal normal normal 12px/1.6em Verdana, Helvetica, Arial, sans-serif; line-height: 1.6em; font-size: 14px; border-top-width: 1px; border-top-style: solid; border-top-color: rgb(193, 193, 193); padding-top: 5px; padding-right: 5px; padding-bottom: 5px; padding-left: 5px; "><br style="word-wrap: break-word; line-height: normal; "/>国际<span href="tag.php?name=%D2%C5%B4%AB%D1%A7" class="t_tag" style="word-wrap: break-word; line-height: normal; cursor: pointer; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(255, 0, 0); white-space: nowrap; ">遗传学</span>杂志 > 2008年6期 <br style="word-wrap: break-word; line-height: normal; "/><br style="word-wrap: break-word; line-height: normal; "/><span href="tag.php?name=%BA%BA%D7%E5" class="t_tag" style="word-wrap: break-word; line-height: normal; cursor: pointer; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(255, 0, 0); white-space: nowrap; "><span class="Apple-style-span" style="word-wrap: break-word; line-height: 22px; ">邕宁</span></span><span href="tag.php?name=%BA%BA%D7%E5" class="t_tag" style="word-wrap: break-word; line-height: normal; cursor: pointer; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(255, 0, 0); white-space: nowrap; ">汉族</span>与周边民族的群体差异分析<br style="word-wrap: break-word; line-height: normal; "/><br style="word-wrap: break-word; line-height: normal; "/>唐剑频 于昕 蒋丰慧 于晓军<br style="word-wrap: break-word; line-height: normal; "/><br style="word-wrap: break-word; line-height: normal; "/>目的：获取15个<span href="tag.php?name=STR" class="t_tag" style="word-wrap: break-word; line-height: normal; cursor: pointer; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(255, 0, 0); white-space: nowrap; ">STR</span>基因座在邕宁地区汉族的群体遗传学和法医学数据,并分析邕宁汉族群体与周边民族群体的遗传关系.<br style="word-wrap: break-word; line-height: normal; "/>方法：利用复合扩增技术,对15个STR基因座进行基因型分型.Arlequin 3.1软件分析群体间遗传差异和遗传距离,用邻接法构建12个群体的系统树.<br style="word-wrap: break-word; line-height: normal; "/>结果：15个STR基因座的多态信息量(polymorphic information content,PIC)为0.51～0.84,观察杂合度为0.59～0.88,期望杂合度为0.54～0.89,个人识别率(discrimination power,DP)为0.77～0.96,非父排除率(probability of exclusion,PE)为0.24～0.77.在TH01基因座,邕宁汉族群体与回族、京族的群体间非差异exact P值均大于0.05.<br style="word-wrap: break-word; line-height: normal; "/>结论：在邕宁汉族与回族、京族之间,TH01基因座的等位基因频率分布无差异.广西各民族间存在着深远的基因交流,具有很高的相同血缘,其中<b style="word-wrap: break-word; line-height: normal; "><font class="Apple-style-span" color="#0000FF" style="word-wrap: break-word; line-height: normal; ">邕宁汉族与壮族、侗族遗传距离最近.</font></b><br style="word-wrap: break-word; line-height: normal; "/><br style="word-wrap: break-word; line-height: normal; "/></td></tr></tbody></table></div></span></div></span></div><div><br/></div><div><br/></div><div><br/></div><div><br/></div><div><br/></div> <div><br/></div><div><span class="Apple-style-span" style="border-collapse: collapse; color: rgb(83, 83, 83); font-family: Arial, Helvetica, sans-serif; font-size: large; word-wrap: break-word; "><div style="word-wrap: break-word; line-height: normal; "><span class="Apple-style-span" style="word-wrap: break-word; line-height: normal; font-size: large; "><br style="word-wrap: break-word; line-height: normal; "/></span></div>「共祖系数」低到几乎为零，说明大多数「族谱」都是攀附伪造。在清代的珠江三角洲，小族「并入」大族，大族又伪造「南迁」族谱，比比皆是。攀附伪造「族谱」现象，在越南朝鲜日本都很普遍。</span><div style="word-wrap: break-word; line-height: normal; "><span class="Apple-style-span" style="word-wrap: break-word; line-height: normal; font-size: large; "><br style="word-wrap: break-word; line-height: normal; "/></span></div><div style="word-wrap: break-word; line-height: normal; "><span class="Apple-style-span" style="word-wrap: break-word; line-height: normal; font-size: large; "><br/></span></div><div style="word-wrap: break-word; line-height: normal; "><span class="Apple-style-span" style="word-wrap: break-word; line-height: normal; font-size: large; "><br/></span></div></div> 所以，真正的学者都不把家谱当信史的。家谱能“仅供参考”就很了不起了。 <p>我手头有本番禺郭氏族谱，到今天，他们的绝对多数是沙田区的居民，老年人都还承认自己是“水上居民”的后裔，但其族谱偏偏要从那伙在南宋时自南雄珠玑巷迁徙而来的人算起。罗贵率领的南迁队伍中确实有郭姓人物，但他并非是三角洲所有郭氏的先祖，更不可能是“疍民”的先祖。</p><p>事实上，由乡村传统私塾毕业的知识分子编写的族谱，漏洞很多，尤其在远祖的附会上最普遍，何况很多族谱是互相抄袭的，同姓之间互相抄袭的现象就更严重了。</p>[此贴子已经被作者于2010-1-17 15:24:44编辑过]
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